Tricuspid Valve Research

At the Minneapolis Heart Institute Foundation (MHIF) Valve Research Center, we're making exciting strides in tricuspid valve research. Our world-class team leads groundbreaking studies and trials that are shaping the future of tricuspid valve care.

Innovations for the “forgotten valve”

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The tricuspid valve is often called "the forgotten valve.” Why? Its problems are more rare and subtle than other valves, and sometimes overlooked in heart health checks. But the tricuspid valve is vital to good health. If someone has a leaky tricuspid valve—also known as tricuspid regurgitation—they may be short of breath, tired, and retain fluid. 

At the Valve Science Center, our world-class team is actively involved in tricuspid research and clinical trials aimed at improving patient outcomes worldwide. This work is in partnership with Allina Health Minneapolis Heart Institute® physicians.

TRILUMINATE pivotal trial and TriClip™ technology

Traditionally, fixing a leaky tricuspid valve requires open-heart surgery, which comes with big risks and a long recovery. The TRILUMINATE pivotal trial focuses on testing the TriClip (manufactured by Abbott), a new device that can fix leaky tricuspid valves without open-heart surgery. Instead, interventional cardiologists use a catheter to implant the TriClip, so the procedure is minimally invasive and has a short recovery time.

 

The highly successful TRILUMINATE trial is revolutionizing  tricuspid valve disease care, and MHIF is proud to be one of its trailblazers. After receiving FDA approval in 2024, the TriClip is now accessible to more patients, providing hope to those who previously had limited treatment options.

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Enroll in a clinical trial

Advancing your own care starts with one simple question. Ask your doctor: “Is research one of my options?” The answer could be the difference in discovering a new treatment you and others may need to live well and manage a challenging heart or vascular condition.

If you or someone you care about would like more information about research participation, talk to your doctor, and learn about the benefits of participating in research as well as how to contact our team:

Patient success story

Tricuspid regurgitation

After open-heart surgery and several rounds of chemo for breast cancer, Chris Jackson developed tricuspid regurgitation, a serious heart valve disease. Chris joined the TRILUMINATE research trial and received a minimally invasive tricuspid valve clip, which fixed her leaky valve and dramatically improved her quality of life.

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The Minneapolis Heart Institute Foundation® (MHIF) strives to create a world without heart and vascular disease. To achieve this bold vision, we are dedicated to improving the cardiovascular health of individuals and communities through innovative research and education.

Thanks to the generosity of donors like you, we can continue this life-saving work. Please make a gift to support lasting change in the lives of individuals we serve and future generations to come.