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Tricuspid Valve Research

At MHIF's Valve Science Center, we're making exciting strides in tricuspid valve research. Our world-class team leads groundbreaking studies and trials that are shaping the future of tricuspid valve care.

stethoscope listening to heart
heart valve diagram

Innovations for the “forgotten valve”

The tricuspid valve is often called "the forgotten valve.” Why? Its problems are more rare and subtle than other valves, and sometimes overlooked in heart health checks. But the tricuspid valve is vital to good health. If someone has a leaky tricuspid valve—also known as tricuspid regurgitation—they may be short of breath, tired, and retain fluid. 

At the Valve Science Center, our world-class team is actively involved in tricuspid research and clinical trials aimed at improving patient outcomes worldwide. This work is in partnership with Allina Health Minneapolis Heart Institute physicians.

TRILUMINATE pivotal trial and TriClip™ technology

Traditionally, fixing a leaky tricuspid valve requires open-heart surgery, which comes with big risks and a long recovery. The TRILUMINATE pivotal trial focuses on testing the TriClip (manufactured by Abbott), a new device that can fix leaky tricuspid valves without open-heart surgery. Instead, interventional cardiologists use a catheter to implant the TriClip, so the procedure is minimally invasive and has a short recovery time.

The highly successful TRILUMINATE trial is revolutionizing  tricuspid valve disease care, and MHIF is proud to be one of its trailblazers. After receiving FDA approval in 2024, the TriClip is now accessible to more patients, providing hope to those who previously had limited treatment options.

Most enrolled
MHIF enrolled the first and most patients in the TRILUMINATE pivotal trial of all the 68 sites in the U.S., Canada and Europe
First in-human use of TriClip
MHIF was the first to provide the TriClip technology to a patient as part of an early research study in 2017
FDA approval for TriClip
MHIF contributed a significant amount of research that earned FDA approval for TriClip

Patient Success Story

Tricuspid regurgitation

After open-heart surgery and several rounds of chemo for breast cancer, Chris Jackson developed tricuspid regurgitation, a serious heart valve disease. Chris joined the TRILUMINATE research trial and received a minimally invasive tricuspid valve clip, which fixed her leaky valve and dramatically improved her quality of life.

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Discover Active Clinical Trials

Our research offers hope for current patients and opportunities to make a difference for future patients. We explore every area of cardiovascular care.