Center for Coronary Artery Disease Professional Resources


The Center for Coronary Artery Disease is strongly positioned for success through:

  • A partnership with 70+ cardiologists who see more than 31,000 patients at nearly 57,000 clinic visits each year at Abbott Northwestern Hospital and 36 outreach sites.
  • An exceptionally large and diverse patient experience, complete with data contained within the electronic medical record as part of Allina Health.
  • A proven track record of dissemination, publishing 63 journal articles (including peer-reviewed) in 2019, along with 25 poster presentations and 48 invited presentations at 22 meetings (15 in the U.S. and 7 internationally.


Frank J. and Eleanor Maslowski Charitable Trust Complex High Risk Indicated Percutaneous Coronary Interventions (CHIP) and Chronic Total Occlusion (CTO) Fellowship

As part of the educational aim for the Center for Coronary Artery Disease, a one-year fellowship in has been created to provide a robust experience to an individual interested in training in complex percutaneous coronary interventions and interventional cardiology research. More information


Our CCAD Research

We are making the impossible possible through innovative research and education around treatment approaches for coronary artery disease cases. Check out our research and resources below.

CTO Manual

A searchable database of complex CTO cases. Resources compiled by faculty at the Center for Coronary Artery Disease.

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PCI Manual

A searchable case library of non-CTO coronary interventions compiled by faculty at the Center for Coronary Artery Disease.

Learn More >


PROGRESS-CTO is an ongoing contemporary, multi-center global registry of more than 7,000 CTO-PCIs at 50 participating centers, with a goal to provide novel insights into the most complex type of CTO-PCIs through rigorous study of techniques and outcomes across a varied group of operators and medical practices.

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PROGRESS-Bifurcation Registry

Approximately 20% (1 in 5) coronary artery lesions involves a branching point (bifurcation). Recanalizing bifurcation lesions can be challenging because the branching artery may become obstructed or completely occluded during the procedure. The recently launched PROGRESS-Bifurcation registry will provide novel insights on the current state and future directions on coronary bifurcation interventions.


This is a randomized prospective trial that will compare Radial artery access to state-of-the-art Femoral artery access for Cardiac Catheterization and PCI procedures. The objective of this trial is to help determine the optimal method for obtaining arterial access in various clinical settings and improve patient outcomes.

CCAD Presentations Map

We are proud to share research and education with peers around the world. Take a look where we’ve presented our research below!


Recent Publications

MHIF’s CCAD team has authored hundreds of papers and presents frequently at national and international conferences. Read some of the latest publications from our team below.

Aug 2021: Laser for balloon uncrossable and undilatable chronic total occlusion interventions

June 2021: Combined use of intravascular lithotripsy and brachytherapy: A new approach for the treatment of recurrent coronary in-stent restenosis

June 2021: Outcomes with Orbital and Rotational Atherectomy for Inpatient Percutaneous Coronary Intervention

June 2021: Chronic total occlusion percutaneous coronary intervention in octogenarians and nonagenarians

June 2021: In-Stent CTO Percutaneous Coronary Intervention: Individual Patient Data Pooled Analysis of 4 Multicenter Registries

June 2021: Chronic Total Occlusion Percutaneous Coronary Intervention during the COVID-19 pandemic: Insights from the PROGRESS-CTO Registry

May 2021: Characteristics and in-hospital outcomes of patients undergoing complex bifurcation versus nonbifurcation percutaneous coronary intervention

May 2021: Management of Coronary Artery Perforation

May 2021: An algorithmic approach to balloon-uncrossable coronary lesions

May 2021: Editorial: With great power comes great responsibility: When and how to use the retrograde approach to chronic total occlusion interventions

May 2021: Trends and outcomes of utilization of thrombectomy during primary percutaneous coronary intervention

May 2021: Multivessel Versus Culprit-Vessel Percutaneous Coronary Intervention in Patients With Non-ST-Segment Elevation Myocardial Infarction and Cardiogenic Shock

April 2021: Current challenges and prevention strategies for chronic total occlusion (CTO) complications

March 2021: An Unusual Treatment for Ventricular Tachycardia

March 2021: ST-segment elevation myocardial infarction due to multivessel, multifocal coronary vasospasm

Feb 2021: Definitions and Clinical Trial Design Principles for Coronary Artery Chronic Total Occlusion Therapies: CTO-ARC Consensus Recommendations

Feb 2021: Can History of Myocardial Infarction Reliably Indicate Myocardial Viability in Patients With a Coronary Chronic Total Occlusion and Good Collateral Circulation?

Feb 2021: Coronary Intravascular Brachytherapy for Recurrent Coronary Drug-Eluting Stent In-Stent Restenosis: A Systematic Review and Meta-Analysis

Feb 2021: Meta-analysis Comparing Outcomes of Percutaneous Coronary Intervention of Native Artery Versus Bypass Graft in Patients With Prior Coronary Artery Bypass Grafting

Feb 2021: Learning and innovation among interventional cardiologists: Insights from an international survey

Jan 2021: Chronic total occlusion percutaneous coronary intervention: managing perforation complications

Jan 2021: Uncrossable and undilatable lesions-A practical approach to optimizing outcomes in PCI

Jan 2021: Use of a totally occluded graft as a conduit for retrograde native artery recanalization

Jan 2021: Predicting Technical Success of Chronic Total Occlusion Percutaneous Coronary Intervention: Comparison of 3 Scores

Recent MAUDE Database studies by Dr. Emmanouil Brilakis


Read more publications on PubMed based on authors:  

Dr. Emmanouil Brilakis 

Dr. Nicholas Burke 

Dr. Bavana V. Rangan  

Dr. Judit Karacsonyi 

Dr. Evangelia Vemmou  

Dr. Ilias Nikolakopoulos  

Grand Rounds Presentations

Watch recordings or view slides from past lectures on coronary artery disease and related topics. 

May 10, 2021  •. Spring Conference Showcase (Recording)

Treatment patterns and outcomes of bifurcation lesions: First results from the Prospective Global Registry for the Study of Bifurcation Lesions Interventions (PROGRESS-BIFURCATION) by Ilias Nikolakopoulos, MD

Chronic total occlusion percutaneous coronary intervention during COVID-19 pandemic: Insights from the PROGRESS-CTO registry by Evangelia Vemmou, MD

November 23, 2020  •  CT imaging of coronary artery plaque: Substrate-based approach to coronary artery disease by Victor Cheng, MD; (Slides) (Recording)

November 9, 2020  •  AHA Preview
Contemporary In-Hospital Outcomes of Chronic Total Occlusion Interventions: Update from the PROGRESS-CTO Multicenter International Registry and Outcomes of Patients with ST Elevation Myocardial Infarction and History of Prior Coronary Artery Bypass Graft Surgery by Judit Karacsonyi, MD, PhD, Research Fellow, Minneapolis Heart Institute Foundation®; (Slides) (Recording)

Radial Versus Femoral Access For Coronary Procedures In Patients With Prior Coronary Artery Bypass Grafting Surgery: An Updated Study-level Meta-analysis by Ilias Nikolakopoulos, MD, Research Fellow, Minneapolis Heart Institute Foundation®; (Slides) (Recording)

May 11, 2020  •  Complete Revascularization in Patients with Multi-Vessel Coronary Artery Disease: Is the Story COMPLETE? by Mohamed A Omer, MD, MSc, Interventional Cardiology Fellow, Minneapolis Heart Institute® at Abbott Northwestern Hospital; (Slides) (Recording)

October 14, 2019 • Engaging MHIF Research: Structural Heart, Electrophysiology and Complex Coronary Artery Disease – Current CCAD Studies by Emmanouil S. Brilakis, MD, PhD, Director, Center for Complex Coronary Artery Disease; (Slides) (Recording)

April 15, 2019 • Update on Chronic Total Occlusion (CTO) Percutaneous Coronary Intervention by Emmanouil S. Brilakis, MD, PhD, Director, Center for Complex Coronary Artery Disease; (Slides) (Recording)

More Grand Rounds


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