The Physiology Course
Hosted by The Center for Coronary Artery Disease

The Physiology Course

The Physiology Course
The latest research and advancements in coronary physiology
June 5-6, 2025
06/05/2025 07:00
Days
Hours
Mins
Secs

Until The Physiology Course Begins

The Minneapolis Heart Institute Foundation® (MHIF) and Allina Health Minneapolis Heart Institute®, in partnership with CoreAalst®, Optima®, and The American College of Cardiology - Minnesota Chapter®, are pleased to present The Physiology Course. Join us as we explore how to use coronary physiology for the assessment of epicardial coronary artery disease and the coronary microcirculation. This educational opportunity is an in-person experience that includes presentations, debates, discussions, hands-on training, and interactive live cases.

Dates: June 5-6, 2025 
Location: MacMillan Center | 2800 10th Ave S, Minneapolis, MN

Our expert faculty will delve into the latest research and advancements in coronary physiology, including wire-based and wireless approaches, providing valuable insights for cardiovascular professionals and researchers alike to improve patient care. Don't miss the opportunity to join this inaugural coronary physiology course in the United States and deepen your understanding of the vital role that coronary physiology plays in modern PCI and the assessment of patients with coronary microvascular dysfunction.

Course Directors
A photograph of Yader Sandoval, MD

Yader Sandoval, MD, FACC, FSCAI, FESC

Interventional Section | Allina Health Minneapolis Heart Institute
Co-Chairman, Center for Coronary Artery Disease | Minneapolis Heart Institute Foundation
Adjunct Associate Professor | Mayo Clinic College of Medicine and Science

A picture of Manos Brilakis, MD

Emmanouil Brilakis, MD, PhD, FACC, FAHA, FESC, FSCAI

Director, Center for Complex Coronary Interventions | Allina Health Minneapolis Heart Institute
Chairman, Center for Coronary Artery Disease | Minneapolis Heart Institute Foundation

A picture of Carlos Collet, MD

Carlos Collet, MD, PhD

Codirector, Catheterization Laboratory | Cardiovascular Center OLV

Bernard De Bruyne, MD, PhD

Bernard De Bruyne, MD, PhD

Interventional Cardiologist | Cardiovascular Center OLV

Faculty
cavalcante

João Cavalcante, MD, FACC, FASE, FSCCT, FSCMR

Section Head, Cardiac Imaging | Allina Health Minneapolis Heart Institute
Director, Cardiovascular Imaging Research Center and Core Lab | Minneapolis Heart Institute Foundation
Inaugural Innovation Chair, Van Tassel Innovation Center | Minneapolis Heart Institute Foundation
 

William Fearon, MD

William Fearon, MD

Professor of Medicine, Chief of the Interventional Cardiology Section | Stanford University School of Medicine
Chief of Cardiology Section | VA Palo Alto Health Care System

Nils P. Johnson, MD, MS

Nils P. Johnson, MD, MS

Professor of Medicine, Weatherhead Distinguished Chair of Heart Disease | McGovern Medical School at UTHealth

Morton J. Kern, MD

Morton J. Kern, MD

Professor of Medicine | University of California, Irvine
Chief of Cardiology | Long Beach Veterans Administration Medical Center

Claire E. Raphael, MBBS, PhD

Claire E. Raphael, MBBS, PhD

Cardiologist, Assistant Professor, Senior Associate Consultant | Mayo Clinic

Arnold Seto, MD, MPA

Arnold Seto, MD, MPA

Interventional Cardiologist, Past Chief of Cardiology | Long Beach VA Medical Center
Associate Clinical Professor | University of California, Irvine
Treasurer | Society of Cardiovascular Angiography and Interventions

Nathaniel R. Smilowitz, MD

Nathaniel R. Smilowitz, MD

Assistant Professor, Department of Medicine | New York University Grossman School of Medicine
Interventional Cardiologist | NYU Langone Health & VA New York 

Jay Traverse

Jay Traverse, MD

Senior Consulting Cardiologist | Allina Health Minneapolis Heart Institute
Associate Professor of Medicine | University of Minnesota Medical School

R. Jay Widmer, MD, PhD

R. Jay Widmer, MD, PhD

Interventional Cardiologist | Baylor Scott & White Health

Agenda

Day 1 - Session 1: Why?
Moderators: Yader Sandoval, MD & Emmanouil Brilakis, MD, PhD

0700-0745 Registration
0745-0800 Introduction | Yader Sandoval, MD; Emmanouil Brilakis, MD, PhD; Bernard De Bruyne, MD, PhD; Carlos Collet, MD, PhD
0800-0812 Why Physiology? | Carlos Collet, MD, PhD
0812-0817 Q&A
0817-0829 How We Got to Now | Bernard De Bruyne, MD, PhD
0829-0834 Q&A
0834-0846 Key Concepts | Nils Johnson, MD, MS
0846-0851 Q&A
0851-0903 The Physiology Toolkit | William Fearon, MD
0903-0908 Q&A
0908-0920 FFR | Morton Kern, MD
0920-0925 Q&A
0925-0937 NHPR | Emmanouil Brilakis, MD, PhD
0937-0942 Q&A
0942-0954 PPG | Yader Sandoval, MD
0954-1000 Q&A
1000-1030 Coffee Break

Day 1 - Session 2: Live Cases by the Allina Health Minneapolis Heart Institute 
Moderators: Carlos Collet, MD, PhD & Bernard De Bruyne, MD, PhD

1030-1200 Live Cases 1 and 2 by the Allina Health Minneapolis Heart Institute | Operators: Yader Sandoval, MD and Emmanouil Brilakis, MD, PhD
1200-1300 Lunch and Networking

Day 1 - Session 3: Non-Invasive and Wireless Physiology
Moderators: William Fearon, MD & Morton Kern, MD

1300-1312 CT-Based Coronary Physiology and Virtual PCI | Yader Sandoval, MD
1312-1317 Q&A
1317-1329 Angiographic FFR | Arnold Seto, MD, MPA
1329-1334 Q&A
1334-1346 Debate: PET for CMD | Nils Johnson, MD, MS
1346-1358 Debate: CMFRI for CMD | João L Cavalcante, MD
1358-1403 Q&A
1403-1410 Hands-On Explanation and Split into Small Groups
Day 1 - Session 4: Hands-On Breakout Sessions
 
1410-1710 Hands-On Breakout Sessions
1710-1730 Day 1 Wrap-Up and Transport to Reception

 

Day 2 - Session 5: Coronary Microvascular Dysfunction - Part 1
Moderators: Carlos Collet, MD, PhD & Bernard De Bruyne, MD, PhD

0745-0800 Day 1 Recap | Carlos Collet, MD, PhD and Bernard De Bruyne, MD, PhD
0800-0812 CFR | Morton Kern, MD
0812-0817 Q&A
0817-0829 Bolus Thermodilution and IMR | William Fearon, MD
0829-0834 Q&A
0834-0846 Continuous Thermodilution and MRR | Bernard De Bruyne, MD, PhD
0846-0900 Q&A and Live Case Transition
Day 2 - Session 6: Live Cases by the Allina Health Minneapolis Heart Institute 
Moderators: William Fearon, MD & Morton Kern, MD
 
0900-1030 Live Cases 3 and 4 by the Allina Health Minneapolis Heart Institute | Operators: Yader Sandoval, MD and Emmanouil Brilakis, MD, PhD
1030-1100 Coffee Break
Day 2 - Session 7: Coronary Microvascular Dysfunction - Part 2
Moderators: Claire Raphael, MBBS, PhD & Nathaniel Smilowitz, MD, MS
 
1100-1112 Doppler-Based Assessment of CMD | R. Jay Widmer, MD, PhD
1112-1117 Q&A
1117-1129 Acetylcholine Spasm Provocation | Claire Raphael, MBBS, PhD
1129-1134 Q&A
1134-1146 Myocardial Bridging | Nathaniel Smilowitz, MD, MS
1146-1151 Q&A
1151-1203 The Chest Pain Clinic | Claire Raphael, MBBS, PhD
1203-1208 Q&A
1208-1220 Best FIT Abstract Presentation
1220-1230 Q&A
1230-1330 Lunch and Networking
Day 2 - Session 8: Lesion Subsets and Key Scenarios
Moderators: Arnold Seto, MD, MPA
 
1330-1340 Serial Lesions: How-to | Nils Johnson, MD, MS
1340-1345 Q&A
1345-1355 Physiology for Complex PCI | Emmanouil Brilakis, MD, PhD
1355-1400 Q&A
1400-1410 Post-PCI Physiology | Yader Sandoval, MD
1410-1415 Q&A
1415-1430 Coffee Break
Day 2 - Session 9: Therapies and Future Directions
 
1430-1440 Medical Therapy for CMD | Nathaniel Smilowitz, MD, MS
1440-1445 Q&A
1445-1455 Microvascular Obstruction in STEMI | Jay Traverse, MD
1455-1500 Q&A
1500-1510 Emerging Interventional Therapies | R. Jay Widmer, MD, PhD
1510-1515 Q&A
1515-1525 Vulnerability: The Next Frontier in Coronary Physiology | Carlos Collet, MD, PhD
1525-1530 Q&A
1530-1540 The 10 Commandments of Coronary Physiology | Bernard De Bruyne, MD, PhD
1540-1545 Q&A
1545-1600 Conclusion and Final Remarks | Yader Sandoval, MD; Emmanouil Brilakis, MD, PhD; Carlos Collet, MD, PhD; Bernard De Bruyne, MD, PhD

 

Challenging Cases & Abstracts Competition

Fellows, Students, & Residents: Share your most challenging, innovative, or educational case or research abstract for a chance to present at The Physiology Course! Selected winners will have the opportunity to showcase their work during the program and receive a travel grant.

Presenter at podium

Case Competition

Please submit your most challenging, innovative or educational case for consideration in The Physiology Course 2025 Challenging Case Competition. Cases will be reviewed by course directors and winners will be selected to present during the conference program.

Presenter at podium

Research Abstracts

The Research Abstracts gallery at The Physiology Course allows early-career researchers to share their work with their colleagues! Abstracts will be reviewed by course directors and winners will be selected to present during the conference.

Thank You to Our Event Partners

CoreAalst, Optima, and Minnesota Chapter of ACC logos
Give the Gift of Hope
4 photos of families smiling

The Minneapolis Heart Institute Foundation® (MHIF) strives to create a world without heart and vascular disease. To achieve this bold vision, we are dedicated to improving the cardiovascular health of individuals and communities through innovative research and education.

Thanks to the generosity of donors like you, we can continue this life-saving work. Please make a gift to support lasting change in the lives of individuals we serve and future generations to come.