COVID-19 Research

As a world-class cardiovascular research and education organization, we know that research and science are the solutions to the COVID-19 pandemic. We join with others around the world, working hard to contribute to solutions.

Real-Time Insight

The Minneapolis Heart Institute Foundation® (MHIF) got involved in important research related to COVID-19 and cardiovascular health early in the pandemic. 

In April 2020, we announced our role as the international coordinating and data center for the North American COVID-19 ST-Segment Elevation Myocardial Infarction Registry (NACMI) in addition to enrolling patients into the study. This registry is a research study designed to collect data on COVID-19 positive patients or persons under investigation (suspected to have COVID-19 infection) with ST-Elevation Myocardial Infarction (STEMI), a serious heart attack involving a blockage in one of the heart's major arteries that supplies oxygen and nutrient-rich blood to the heart muscle. 

The goal of the research was to provide physicians real-time insight into the clinical characteristics, treatment strategies, and outcomes of STEMI patients with COVID-19 infection. The registry had the potential to provide critically important time-sensitive data to inform the management and treatment guidelines applicable to COVID-19 patients. 

Covid Registry

On the Pulse: COVID-19

Dr. Emmanouil Brilakis and Dr. Santiago Garcia speak on COVID-19 and why you should still take care of your heart. 

“This research is a critical example of how real-time collection of data has the potential to guide insights that can benefit patient outcomes while we’re learning minute-by-minute during this pandemic. We are proud of our extensive MHIF research on STEMI that arms us to quickly deploy this new study in partnership with other colleagues across North America. We look forward to collaborating and rapidly sharing clinical guidance that will come from this unique registry.” 


- Dr. Santiago Garcia

Publication of NACMI Research

In April 2021, MHIF announced the first publication of outcomes from the NACMI research showing that COVID-positive patients with STEMI represent a high-risk group of patients with unique demographic and clinical characteristics that are important to consider in providing optimal care. Read the full press release.

In April 2022, two-year findings were released. The findings included:

Minorities were disproportionally affected:

Nearly 50 percent of the STEMI patients had minority ethnicity (23 percent Hispanic; 24 percent Black)

In-hospital mortality was high

33 percent (4% for controls without COVID)

Symptoms were unique

The majority (54 percent) presented with respiratory symptoms (shortness of breath) rather than chest pain.

Significant proportion of COVID-positive patients presented with high-risk STEMI

Including cardiogenic shock (18 percent) and cardiac arrest (11 percent), which may explain the high fatality rate

Give the Gift of Hope
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The Minneapolis Heart Institute Foundation® (MHIF) strives to create a world without heart and vascular disease. To achieve this bold vision, we are dedicated to improving the cardiovascular health of individuals and communities through innovative research and education.

Thanks to the generosity of donors like you, we can continue this life-saving work. Please make a gift to support the area of greatest need.

Brad Paisley at Heart 360: Concert for Heart Research

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Brad Paisley at Heart 360 Concert

Ready to celebrate with a community that has heart? We are excited to announce Heart 360 Concert for Heart Research on Saturday, November 2 at The Armory with headliner and award-winning country music singer Brad Paisley! Purchase GA tickets via Ticketmaster, or Premium VIP tickets today: