Valve Science Center

Professional Resources

The Valve Science Center is a world-class research and education center for heart valve disease.

As a world leader in cardiac valve disease research, we actively participate in major clinical trials and conduct research pursued by leading physicians to understand valve disease and apply new treatment, diagnosis or monitoring methods. We are committed to translating heart valve disease research findings, implementing the learnings into routine clinical practice and widely sharing the information nationally and globally.

Leading the way in improving care and outcomes for valve patients, we are are recognized for notable “firsts”, including:

• First implant in world’s first pivotal trial (large study used to seek regulatory approval for the device) to evaluate a new approach for repairing leaky tricuspid heart valves —  2019
• First-in-human therapy of tricuspid regurgitation with the TriClip — 2017
• First-in-human therapy of severe mitral annular calcification using the Tendyne mitral prosthesis — 2017
• First-in-human therapy of hypertrophic cardiomyopathy with MitraClip — 2016
• First transcatheter mitral valve replacement in the U.S. with the Tendyne bioprosthetic mitral valve — 2015
– The center is a world-class leader in mitral valve replacement and remains the most experienced site in the world
• First-in-human therapy with the Myocor device for treatment of mitral regurgitation — 2008

Recent Valve Science Center Publications

MHIF’s valve team has authored hundreds of papers and presents frequently at national and international conferences. Read some of the latest publications from our team below.

Nov 2020: Point-of-care ultrasound: Closing guideline gaps in screening for valvular heart disease

Nov 2020: Impact of adherence to the hybrid algorithm for initial crossing strategy selection in chronic total occlusion percutaneous coronary intervention

Oct 2020: “Commissural drop” wiring technique facilitates catheter crossing of severely stenotic aortic valve

Oct 2020: Early Effects of Transcatheter Edge-to-Edge Leaflet Repair for Tricuspid Regurgitation: First-in-Human Experience with Computed Tomography

Oct 2020: Short- and Long-Term Outcomes in Patients With New-Onset Persistent Left Bundle Branch Block After Transcatheter Aortic Valve Replacement

Oct 2020: Impact of Intravascular Ultrasound Utilization for Stent Optimization on 1-Year Outcomes After Chronic Total Occlusion Percutaneous Coronary Intervention

Oct 2020: Changes in quality of life in patients with low-flow aortic stenosis undergoing transcatheter aortic valve replacement

Sept 2020: Left Ventricular Remodeling After Transcatheter Mitral Valve Replacement With Tendyne: New Insights From Computed Tomography

Sept 2020: Neo-Left Ventricular Outflow Tract Modification With Alcohol Septal Ablation Before Tendyne Transcatheter Mitral Valve Replacement

Sept 2020: Ischemic Stroke With Cerebral Protection System During Transcatheter Aortic Valve Replacement

Sept 2020: Identification of Subclinical Myocardial Dysfunction and Association with Survival after Transcatheter Mitral Valve Repair

Sept 2020: Assessment of aortic bioprosthetic valve fracture by Computed Tomography Angiography

July 2020: Challenges of Left Atrial Appendage Occlusion Using a Watchman After Transcatheter Mitral Valve Implantation With a Tendyne

June 2020: Transcatheter aortic valve replacement in patients with severe comorbidities: A retrospective cohort study

June 2020: Percutaneous Mitral Valve Repair With MitraClip in Inoperable Patients With Severe Mitral Regurgitation Complicated by Cardiogenic Shock

June 2020: Temporal Trends and Outcomes of Transcatheter Mitral Valve Repair Among Nonagenarians

April 2020: Incidence and Outcomes of Acute Coronary Syndrome After Transcatheter Aortic Valve Replacement

April 2020: Double-Kiss-Crush Bifurcation Stenting: Step-by-Step Troubleshooting

April 2020: Impact of the Commercial Introduction of Transcatheter Mitral Valve Repair on Mitral Surgical Practice

April 2020: Invasive versus non-invasive assessment of valvuloarterial impedance in severe aortic stenosis

The following two publications were included in the Editor-in-Chief’s Top 100 Picks from 2019 in the Journal of the American College of Cardiology:

Initial feasibility study of a new transcatheter mitral prosthesis: the first 100 patients

Novel transcatheter mitral valve prosthesis for patients with severe mitral annular calcification

Read more publications on PubMed based on authors:

Dr. Paul Sorajja

Dr. Mario Goessl

Dr. Richard Bae

Dr. João Cavalcante

Dr. Santiago Garcia

Dr. Kevin Harris

Dr. John Lesser

Dr. Benjamin Sun

Valvular Heart Health Lectures from MHIF Grand Rounds

Watch recordings or view slides from past lectures on heart valve disease and related topics. 

Oct. 12, 2020 • Mitral valve prolapse – when does it stop being benign? By Iulia Tulai, MD, Cardiology Fellow, Minneapolis Heart Institute® at Abbott Northwestern Hospital & Hennepin Healthcare (Slides) (Recording)

September 14, 2020 • The Conundrum of Functional Mitral Regurgitation by Maurice Enriquez-Sarano, MD (Slides) (Recording)

April 13, 2020 • Mitral Valve Surgery by Robert J Steffen, MD (Slides) (Recording)

January 20, 2020 • Update of Tricuspid Regurgitation: Evaluation and Treatment by Anene Ukaigwe, MB, BS (Slides) (Recording)

October 14, 2019 • Structural Heart Update 2019 by Paul Sorajja, MD (Slides) (Recording)

September 9, 2019 • Health Care Disparities in Structural Heart Disease – TVINCITIES Update by Mario Gössl, MD, PhD  (Slides) (Recording)

April 22, 2019 • Multimodality Imaging for Valvular Disease – In Whom, When and Why? by João L. Cavalcante, MD, FACC, FSCMR, FSCCT (Slides) (Recording)

December 17, 2018 • The intersection of heart failure and structural cardiology by Peter Eckman, MD, FACC, FHFSA and Paul Sorajja, MD (Slides) (Recording)

January 22, 2018 • Transcatheter Valve Therapy (TVT) 2018 by Paul Sorajja, MD (Slides) (Recording)

Find more MHIF Grand Round Lectures here >>

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