Research Capabilities

What Makes MHIF Unique?

Over the course of its 35-year history, the Minneapolis Heart Institute Foundation® (MHIF) has cemented its reputation as a premier cardiovascular research facility known for innovation and integrity.

MHIF is co-located with the Minneapolis Heart Institute® at Abbott Northwestern Hospital, which gives our research staff unparalleled access to a world-class facility and its practitioners, as well as a large and diverse patient population. As an independent organization not affiliated with a university or major health system, MHIF is able to act with agility throughout the entire research process, from startup to enrollment to analysis.

Our research covers the spectrum of cardiovascular disease, and studies include both industry-sponsored and investigator-initiated research. This has resulted in game-changing innovations and initiatives that have changed the way cardiovascular disease is prevented, diagnosed and treated.

35 Years of Research and Counting!

With 35 years of research experience, the Minneapolis Heart Institute Foundation® (MHIF) has conducted hundreds of studies covering a wide spectrum of cardiovascular care. Research with MHIF offers many advantages:

  • Access to patient and community populations – Through our affiliation with Minneapolis Heart Institute® (MHI), Abbott Northwestern Hospital and the Allina Health care system, MHIF enrolls almost 1,000 research subjects each year.
  • Thought leaders – The physicians of MHI at Abbott Northwestern Hospital and our team of investigators possess deep knowledge of more than 30 cardiovascular specialties. They are leaders in their fields, recognized at scientific meetings and publish more than 120 peer-reviewed manuscripts every year.
  • Staff experience – MHIF staff have extensive experience from diverse academic and clinical backgrounds. Most of our coordinators are certified Clinical Research Coordinators.
  • Institutional review boards – MHIF works with two reputable institutional review boards in support of our commitment to ethical research.

Leading the Field in Population Health Research

More people are surviving heart attacks today thanks to the MHIF Level One program. Using MHIF data, researchers developed a protocol for the rapid transfer of patients with heart attacks who present to hospitals that lack advanced cardiovascular capabilities. Level One has proven that rural patients, when appropriately treated, can expect the same care and outcomes as those who present to major medical centers. Level One has been replicated globally.

Translating Research into Practice

Partnering with MHI means that research findings are applied to clinical knowledge more quickly. Physicians are able to immediately employ the latest approved techniques to bring about the best outcomes. MHIF also delivers targeted, best-in-class educational programs to help translate research into practice across the country and around the world.

“I DIDN’T HAVE ANY DOUBTS. I HAD FULL TRUST IN THE PEOPLE WHO TOOK CARE OF ME.”

 

JANELL WEBER: AORTIC STENOSIS  |  See Full Story >

 

“I’M A STRONG BELIEVER IN RESEARCH AND TECHNOLOGY. THE TECHNOLOGY SAVED MY LIFE.”

 

MARK PITZELE: LVAD  |  See Full Story >

“I COULDN’T BELIEVE THAT I’D EVEN HAD SURGERY!”

PETRINA CORDES: CARDIAC VALVE  |  See Full Story > 

“AS AN UNDERGRAD, IT’S REALLY RARE TO GET ANY CLINICAL RESEARCH EXPERIENCE, LET ALONE TO HAVE RESEARCH PRESENTED. I’M REALLY FORTUNATE TO HAVE LANDED HERE.”

AKILA PAI: MHIF RESEARCH INTERN  |  See Full Story > 

Procedure Volume

Through our partnership with the MHI at Abbott Northwestern Hospital, we have direct access to a large patient population and a substantial volume of data. Our physician researchers conduct more than 75,000 clinic visits per year. Learn More About Our Physicians ›

Procedures Performed Annually

Cardiac Catheterizations

Cardiac Pci's

Heart Transplants

Venticular assist device implants

EP LAB DEVICE IMPLANTS

Cardiac MRI/CT SCANS

CABG's AND VALVE SURGERIES

Endovascular Aneurysm Repairs

Groundbreaking Work
  • 55 and Under Registry: The first of its kind for identifying younger patients with coronary artery disease, cerebral vascular disease and peripheral vascular disease.
  • HCM Center: Conducts research and offers advice and assistance to individuals who have been diagnosed with HCM, many of whom arrive at HCM with a significantly diminished quality of life and no options for treatment.
  • Level One: Designed to reduce door-to-balloon stent time for those suffering a heart attack, the Level One Heart Attack program coordinates community ER departments, ER transportation professionals, and a constantly available angioplasty team. Since its inception, it has reduced heart attack deaths by more than 50 percent in facilities in which it is practiced.
  • Optimist Program: By providing a variety of novel treatment options for people with heart disease who are not helped by standard treatments, the Optimist Program aims to offer people the opportunity to live a healthier, more satisfying life.
  • CCTRN (Concert/Seneca): The Clinical Nurse Coordinator Core Curriculum Training program at MHIF trains nurses in clinical research coordination and cardiovascular cell therapy nursing care.
  • Hearts Beat Back®: The Heart of New Ulm Project: HONU is a groundbreaking initiative aimed at reducing heart disease throughout the city of New Ulm, Minnesota by focusing on preventing cardiovascular disease versus treating it after it occurs.
  • Cool-It: In order to improve survival and neurologic outcomes after sudden cardiac arrest, Cool-It manages body temperature to give the body sufficient time to recover. This protocol has become standard practice in hospitals across the country.
  • Tendyne/TAVR/TMVR: The MHIF Valve Science Center leads the industry in minimally invasive, non-surgical valve repair and replacement.
Outstanding Research Facilities and Partners

MHIF is located on the campus of Abbott Northwestern Hospital in Minneapolis, MN. As a nonacademic, nonprofit research center, we combine the agility of a midsize nonprofit with the patient and facilities of a major tertiary care center.

Facility at MHIF:

  • World-class laboratory (CLIA- and IATA-certified)
  • Dedicated study monitoring space
  • Advanced cardiovascular imaging center, including a Siemens Flash CT scanner
  • –70°F and –20°F degree freezers
  • ABI testing equipment
  • Secure onsite storage for drugs and devices

 

Facility at Abbott Northwestern Hospital

  • 128-bed heart hospital with pharmacy access
  • Diagnostic and testing equipment: EKG, CXR, Holter monitor, stress, nuclear, MV02, PET scan, MRI/MRA 2D and 3D echo
  • Access to Allina Health electronic health records, a robust database including records from 13 hospitals, 192 clinics, 12 urgent care facilities and 15 pharmacies
Industry Partners

At MHIF, we pride ourselves on the partnerships we’ve formed with cardiovascular industry organizations. The following are a few of our recent partners:

  • Medtronic, PLC
  • Boston Scientific
  • Gore
  • Tendyne Holdings, LLC
  • Abbott Vascular
  • Pfizer
  • Astra Zeneca
  • Gilead
  • Janssen
  • St. Jude Medical
  • Boehinger Ingelheim
  • Novartis
  • Covance
  • ReCor Medical
Institutional Review Board (IRB) Partners

The MHIF has established partnerships with the following IRB organizations:

  • Quorum Review IRB
  • Schulman IRB
Spanning the Spectrum of Study Types

MHIF researchers have deep experience in a wide variety of study types, including:

  • Proof-of-concept
  • Phase I-IV IND and IDE
  • Post-market surveillance
  • Medical device development (feasibility, pilot, pivotal)
  • Imaging (CT, MRI)/core lab
  • Population health
  • Registry
Digging Deep into Data

The MHIF researchers have access to a complex set of data via several national databases and registries. Our extensive data access includes:

OPTIMIST Database More than 1,400 refractory angina patients with annual follow-up data

Level 1 STEMI Database 4,100 STEMI patients; includes follow-up data at 30 days, 1 year, and 5 years

CSI Imaging Database More than 35,000 CT and MRI scans

U.S.National Registry of Sudden Death in Athletes 2,452 victims and 242 survivors of sudden cardiac events, ages 8–39, 1980 to present

National Commotio Cordis Registry 225 (U.S.) and 66 (international) victims and survivors, all ages

MHI Hypertrophic Cardiomyopathy (HCM) Center Patient Database 1,584 patients seen from 1992 to present

Complex Valve Database More than 350 patients with mixed valvular disease

CASE STUDY: Level One Heart Attack Program


More people are surviving heart attacks today thanks to the MHIF Level One program. Using MHIF data, researchers developed a protocol for the rapid transfer of patients with heart attacks who present to hospitals that lack advanced cardiovascular capabilities. Level One has proven that rural patients, when appropriately treated, can expect the same care and outcomes as those who present to major medical centers. Level One has been replicated globally.

For inquiries about our research, please contact us: research@mhif.org 612-863-3980

To see a list of our current active research studies, click here.