Clinical Research Studies

Search our active and enrolling clinical research studies and see if you may qualify to participate.



The primary purpose of this trial is to determine the safety of XC001 (AdVEGFXC1) in patients who suffer from angina caused by coronary artery disease and have no other treatment options. Subjects in this study will receive one of four intramyocardial doses of XC001 that expresses human vascular endothelial growth factor (VEGF) which induces therapeutic angiogenesis (revascularization).


acute kidney injury (AKI) following coronary artery bypass graft (CABG) and/or valve surgery

The purpose of this study is to evaluate the efficacy of postsurgery treatment with ASP1128 in subjects at risk for acute kidney injury (AKI) following CABG and/or valve surgery. This study will also investigate the safety and tolerability of postsurgery treatment with ASP1128, and pharmacokinetic characteristics of ASP1128 in subjects at risk for AKI following CABG and/or valve surgery.

PFO Occluder PAS

ischemic stroke

The purpose of this single arm, multi-center study is to confirm the safety and effectiveness of the AMPLATZER™ PFO Occluder in the post Approval Setting.

MitraClip Expand G4

mitral valve regurgitation

This primary objective of the EXPAND G4 study is to confirm the safety and performance of the MitraClip G4 System in a post-market setting.


ischemic stroke with presence of Patent Foramen Ovale (PFO)

This study will assess the safety and effectiveness of GORE® CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting.

Questions about research options? Contact us.

Sign Up For Our Newsletter

Stay up to date on MHIF news, events and the latest information on heart disease treatment and prevention.