Postconditioning II in STEMI

STUDY IDENTIFIER:

Postconditioning II in STEMI

CONDITION:

Acute Myocardial Infarction

CONTACT INFO:

Jane Fox   |   Jane.Fox@allina.com   |   612-863-6289

DESCRIPTION:

This study will evaluate change in heart muscle function from baseline to three months and twelve months in participants who present with a heart attack and a completely occluded coronary artery. These subjects will be randomized to receive standard Percutaneous transluminal coronary angioplasty (PTCA)/Stenting to open the artery or routine PTCA/Stenting plus post conditioning. Post conditioning commences immediately upon reperfusion using four cycles of thirty second inflations with a standard angioplasty balloon followed by a thirty seconds of reperfusion. The investigators hypothesize that Postconditioning reduces the size of the heart attack when utilized with successful primary Angioplasty/stent.

CRITERIA LIST/ QUALIFICATIONS:

  • Able to undergo cMRl.
  • ST-segment elevation infarction with 100% occlusion of a major epicardial vessel (> 2.5 mm).
  • No angiographic evidence of collateral flow distal to occluded artery.
  • Ischemic duration between 1.0 and 6 hours.
  • TIMI 3 Flow following PCI.

INVESTIGATORS:

Jay Traverse, MD

SPONSORS:

Minneapolis Heart Institute Foundation; National Heart, Lung, and Blood Institute (NHLBI)

STATUS:

Closed

Results:

Patients with a heart attack undergoing treatment with postconditioning experienced similar heart damage when compared to the standard treatment for a heart attack. This method did not reduce heart attack damage but was as safe as the traditional method of angioplasty which is currently used. Forthcoming analysis of 3-mo and 1-year MRIs will reveal if a late benefit of postconditioning occurs.