This study will evaluate change in heart muscle function from baseline to three months and twelve months in participants who present with a heart attack and a completely occluded coronary artery. These subjects will be randomized to receive standard Percutaneous transluminal coronary angioplasty (PTCA)/Stenting to open the artery or routine PTCA/Stenting plus post conditioning. Post conditioning commences immediately upon reperfusion using four cycles of thirty second inflations with a standard angioplasty balloon followed by a thirty seconds of reperfusion. The investigators hypothesize that Postconditioning reduces the size of the heart attack when utilized with successful primary Angioplasty/stent.
CRITERIA LIST/ QUALIFICATIONS:
Able to undergo cMRl.
ST-segment elevation infarction with 100% occlusion of a major epicardial vessel (> 2.5 mm).
No angiographic evidence of collateral flow distal to occluded artery.
Ischemic duration between 1.0 and 6 hours.
TIMI 3 Flow following PCI.
Jay Traverse, MD
Minneapolis Heart Institute Foundation; National Heart, Lung, and Blood Institute (NHLBI)
Patients with a heart attack undergoing treatment with postconditioning experienced similar heart damage when compared to the standard treatment for a heart attack. This method did not reduce heart attack damage but was as safe as the traditional method of angioplasty which is currently used. Forthcoming analysis of 3-mo and 1-year MRIs will reveal if a late benefit of postconditioning occurs.