Clinical Research Studies
We do research across every area of cardiovascular care. Our research offers hope for patients, options to discuss with your doctor, and opportunities to make a difference for future patients. See the search below for a list of our active and enrolling clinical research studies and see if you may qualify to participate.
Benefits of Research
Be More Active
Take a more active role in your own health care.
Potential to Unlock More Options
You may gain access to investigational treatments and medications.
Make a Contribution
Help find a new and better way to treat people with your condition.
Search for research studies
ParadigmStudy Investigator:
Mario Goessl, MD
About the Study:The Paradigm study is a prospective, multicenter, single arm study to demonstrate the safety and effectiveness of the AVP III as a treatment for clinically significant PVLs following surgical implant of a mechanical or biological heart valve implanted in the aortic or mitral position. Condition:
Valvular Disease (Heart Valve Disease)
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Optimize ProStudy Investigator:
Paul Sorajja, MD
About the Study:The purpose of this study is to collect clinical evidence on valve performance and procedural outcomes associated with an "optimized" TAVR care pathway and post-TAVR conduction disturbance pathway while using the Evolut™ PRO and Evolut™ PRO+ devices. Condition:
Valvular Disease (Heart Valve Disease)
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NASAStudy Investigator:
Emmanouil Brilakis, MD
About the Study:The primary study objective of the NASA registry is to evaluate the 12-month incidence of target vessel failure (TVF) in patients who present with saphenous vein graft (SVG) lesions and undergo percutaneous coronary intervention (PCI) of the corresponding native coronary artery. Condition:
Coronary Artery Disease
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INTREPID TMVRStudy Investigator:
Vinayak Bapat, MD
About the Study:PILOT: The study is pilot trial to evaluate the safety and performance of the Twelve TMVR System in very high-risk mitral regurgitation patients. EFS: The study is an EFS trial to evaluate the safety and performance of the Medtronic Intrepid™ Transcatheter Mitral Valve Replacement System with Transfemoral Transseptal access in patients with severe, symptomatic mitral regurgitation. Condition:
Valvular Disease (Heart Valve Disease), Vascular Disease (Peripheral Arterial Disease)
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GE OCTStudy Investigator:
Emmanouil Brilakis, MD
About the Study:The study aims to compare (a) volume contrast administered for Optical Coherence Tomography (OCT) Imaging, (b) length of clear OCT images, and (c) electrocardiographic changes immediately after contrast injection between iso-osmolar and low-osmolar contrast agents. The study is a prospective, single-centered, randomized controlled, study that will compare an iso-osmolar vs. a low-osmolar contrast agent in patients undergoing clinically indicated coronary OCT imaging. Each patient will be randomized to OCT acquisition. Condition:
Coronary Artery Disease
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