Complex Coronary Artery Disease
Science Center

Making the impossible possible through innovative research and education around treatment approaches for the most complex of coronary artery disease cases.


A contemporary, multi-center registry of chronic total occlusion percutaneous coronary interventions

CTO Manual

A searchable database of complex CTO cases. Resources compiled by Dr. Emmanouil Brilakis and Dr. Peter Tajti.

Latest News

Life After Stent

Have you or a loved one had angioplasty with or without stenting? If so, you may have questions about what comes next and what lifestyle adjustments you...

MHIF Fellow, Dr. Peter Tajti wins TCT Fellow Case Competition

This year at Transcatheter Cardiovascular Therapeutics (TCT), Dr. Peter Tajti's presented a case from Minneapolis Heart Institute® that received second place in the International Fellows Challenging Case...

Randomized Comparison of a CrossBoss First vs. Standard Wire Escalation Strategy for Crossing Coronary Chronic Total Occlusions: the “CrossBoss First” trial

MHIF Researcher, Dr. Manos Brilakis presented a first report investigation from CrossBoss First: A Randomized Trial of Antegrade Dissection and Re-entry vs Standard Wire Escalation for Crossing Coronary Artery Chronic Total Occlusions at the Transcatheter Cardiovascular Therapeutics conference in Denver, CO last week.