John and Susan Morrison Intern
Hometown: Maple Grove, MN
Education: Carleton College
MD Mentor: Dr. Jay Traverse
Staff Mentor: Pam Morley
Projects: Determination of the Clinical Factors that Contribute to the Development of Microvascular Obstruction (MVO) Following STEMI; Cardiac Implantable Electronic Device (CIED) Longevity and Reliability
Ananya Shah began her junior year at Carleton College in the fall of 2020 and is studying chemistry and sociology/anthropology. Ananya aspires to become a physician and was drawn to the MHIF clinical research internship program because of the combination of research and clinical experience that the program offers. She appreciated the uniqueness of MHIF’s program in that it allows for the opportunity to interact closely with physicians and conduct research simultaneously.
“I learned so much from this experience,” said Ananya. “I learned the importance of clinical research and translational medicine, and even got to play a small role in it! I also learned so much about the field of cardiology and the anatomy of the heart. I am so amazed at how much I learned, but am also excited about all of the possibilities there are to explore within cardiology. This experience, paired with my desire to pursue a career in service as a lifelong learner and educator, has helped me in my journey to wanting to become a physician.”
Ananya said she particularly enjoyed getting to know the two other interns, as they both brought unique experiences to the table from which she had the opportunity to learn.
“One part of the internship that really struck me was the history and the progression of the field of cardiology,” said Ananya. “I was so amazed to see how far pacemakers, heart transplants and drugs have come in around 100 years. It is also so cool that so much of the discovery is rooted in Minnesota. I was also very fascinated by the women’s heart health initiatives that MHIF was taking. I never realized how large the discrepancies in treating cardiovascular disease in men and women are, so it was very cool to learn about this and see initiatives in action.”
About the Research
Throughout the summer, Ananya worked on two research projects. Under the guidance of Dr. Jay Traverse, she worked on Determination of the Clinical Factors that Contribute to Microvascular Obstruction (MVO) Following STEMI. Since the development of MVO has become an important predictor of adverse left ventricular remodeling, heart failure and other major adverse cardiac events, minimizing MVO remains the most important remaining area in infarct size mitigation in STEMI. The goal of the project was to analyze clinical factors to determine if they had an impact on the presence of MVO. The key finding from the research was that MVO is associated with increased left ventricular end‐diastolic pressure; suggesting the importance of extravascular compressive forces in causing MVO.
Under Dr. Jay Sengupta and Dr. Robert Hauser, Ananya worked on the Cardiac Implantable Electronic Device (CIED) Longevity and Reliability study. The project analyzes the survival of patients who had CIED devices implanted and/or followed at Minneapolis Heart Institute® from 2000-2019, which is the longest study of its kind. The goals were to evaluate device malfunction, battery depletion, wound complications and lead problems of CIEDs from various manufacturers and analyze the survival of patients with CIEDs according to underlying disease. Analyzing these factors has the potential to affect manufacturers’ development of CIEDs to make them more patient-friendly.